Mesotherapy Filorga - a cosmetic procedure against age-related changes 

Composition and properties

The mesotherapy cocktail NCTF 135 HA+, like its predecessors (NCTF 135 and NCTF 135 HA), consists of hyaluronic acid of non-animal origin. The most concentrated drug in the line - the content of the main component in it is 10 mg / ml. The cocktail contains 12 vitamins, 2 antioxidants, 5 nucleosides, 6 minerals, 6 coenzymes and 20 amino acids (+ 3 related compounds).

Hyaluronic acid is of primary importance for the longest possible preservation of skin youth due to its hydrating properties. Dehydration of the dermis and epidermis is a factor that has an extremely negative effect on its visual condition. Dehydration is caused by both natural age-related changes and other etiological reasons - abuse of insolation, living in environmentally unfavorable conditions, smoking, systemic diseases, etc.

Injections of preparations based on hyaluronic acid are a sure and affordable way to maintain the beauty of the skin.

In addition to hyaluronic acid, NCTF 135 HA+ includes:

• Vitamins (A, C, E, I ) – protect cell membranes from harmful exogenous influences, tone capillary walls, lighten melasma and chloasma, neutralize inflammation, participate in biochemical and metabolic reactions;
• B vitamins – inhibit the aging process, accelerate local metabolism, increase cellular respiration, regulate carbohydrate, protein and lipid metabolism in cells, stimulate the production of fibroblasts;
• Minerals – adjust the ionic balance in cells, optimize tissue metabolism, activate lymph flow and blood microcirculation;
• Amino acids - have a positive effect on the fibers of the elastin-collagen framework, restore elasticity and firmness to the skin, increase protective forces;
• Nucleotides - produce DNA and RNA acids, strengthen their molecular chains, organize amino acid compounds in the process of protein synthesis;
• Antioxidants – prevent free radical oxidation in the cells of the epidermis and dermis;
• Coenzymes - provide detoxification and eliminate decay products from tissues, help accelerate the processes of proliferation and regeneration in tissues, and establish energy balance in cells.

NCTF 135 - correct anti-aging mesotherapy

Let's try to understand mesopreparations to combat skin aging.

It won’t be very short, so if you’re afraid of “many letters,” you can safely skip to the end.

The term “age-related skin changes” combines several signs: decreased elasticity and firmness of the skin, heterogeneity of color and microrelief, dryness, the appearance of new or sharp deepening of familiar wrinkles, sagging and displacement of anatomical zones of the face - gravitational ptosis. Most of the above clinical manifestations are based on a decrease in the synthetic activity of fibroblasts.

It describes what happens in aging skin >> - very concisely.

If you don’t know what a fibroblast is, read the brief structure of the skin >>, otherwise it will be difficult further.

So, in order to prevent or even eliminate the signs of skin aging, fibroblasts need to synthesize collagen, hyaluronic acid and other components at a sufficient speed - just as they did in their youth.

This can be achieved in two ways:

1. force
2. create conditions for work.

The first option is technically simpler. Therefore, when developing mesopreparations, most manufacturers focus their efforts on searching for signaling biomolecules that can influence fibroblast receptors and give it a command to increase synthesis. Signal molecules are like a “commander” who forces the “subordinate” to work hard.

This approach does not take into account two basic principles of fibroblast operation:

1. the fibroblast must have a sufficient supply of substrate (raw materials) for synthesis.
2. the fibroblast must have sufficient potential to increase energy , since most synthesis reactions are energy-consuming. But in aging fibroblasts, the energy potential is significantly reduced. As a result, cells have enough energy to maintain life, but not enough for active synthesis. Under such conditions, an aging cell often spends its last reserves of scarce materials and energy. This can significantly shorten its lifespan and lead to rapid death.

Difficult? Let's keep it simple.

1. The skin needs to be restored. Only fibroblasts can do this.
2. To produce everything they need, they need materials and energy. If they exist, everything is fine, there will be a result.
3. There are no materials - it is useless to yell at the worker; you need to have something to make products from.
4. There is no energy reserve - the fibroblast will tear itself or die trying to carry out the order.

Is that clearer?

The problem is that we cannot say for sure whether a particular patient's skin fibroblasts have enough of everything at a particular moment. But the most surprising thing is that many cosmetologists are not interested . The main thing is to show the patient immediate results, and at what cost is not important.

But it is obvious that the older the cell, the more biochemical “damages” it has accumulated, the fewer resources it has, the weaker the response to stimulation will be. After all, the fibroblast is as old as the patient! Therefore, working with stimulants (whatever you call them - signal peptides, command biomolecules, etc.) is a bit of a lottery.

The Filorga laboratory took another principle as a basis - a mesopreparation for anti-aging therapy should help the fibroblast carry out its functions , and not force it.

NCTF 135 - enriched and super-enriched, Filorga mesotherapy
To implement this principle, the drug must contain active substances that will form a microenvironment comfortable for the cell, and insure key biochemical processes in the fibroblast while increasing its synthetic activity.

Thanks to this approach, in the 90s, the Filorga Laboratory released a line of mesopreparations based on NCTF 135 . The formula contains a full range of ingredients necessary to restore activity and protect skin cells. Vitamins, amino acids, minerals, coenzymes, nucleotides, antioxidants - more than 50 components in total! Their action is supplemented with high molecular weight hyaluronic acid.

Reference mesopreparation: Filorga NCTF 135 HA+

Such a complex composition includes everything that fibroblast needs for enhanced synthesis of collagen, hyaluronic acid and other skin components. Everything is not just raw materials! These are the components necessary to quickly increase the cell’s energy production, and to protect it from oxidative stress, and to transport all these reserves into the cell.

That is, the developers of Filorgi spent a long time figuring out which substances are often deficient in age-related fibroblasts, and then managed to collect them into one drug. And the doctor, using NCTF, does not have to worry about whether this patient’s fibroblasts have enough vitamin C, or respiratory enzymes, or something else. Everything you need to work at NCTF is already there, the cage is fully insured!

NCTF does not force fibroblasts to increase production, but creates normal conditions for this . And “fed” fibroblasts calmly increase the synthesis of collagen and hyaluronic acid significantly, without overexerting themselves with all their might. As a result, we get restoration of the structure of aging skin and normalization of biochemical processes in it. The resistance of fibroblasts to damaging influences – ultraviolet radiation, tobacco smoke, etc. – increases.

After some time, fibroblasts will again accumulate internal problems, and they will again reduce their synthesis. Then the course of mesotherapy is repeated. Usually, 1-2 courses per year of 4-6 procedures are sufficient to maintain normal fibroblast activity.

NCTF 135 HA mesotherapy Filorga

The second use of NCTF135 is preparing the skin for aggressive influences and restoring them after them. This includes plastic surgery, harsh peelings, laser resurfacing, and a trip to the south under ultraviolet exposure. After all, to restore the skin, you need the same elements, only in even larger quantities and preferably faster. That is, the fibroblast “factory” must produce even more products than usual, and help in the form of NCTF comes in very handy.

Scope of application of NCTF 135 HA+ in cosmetology

The drug NCTF 135 HA+ is used in cosmetology for mesotherapy and biorevitalization procedures. They are injectable and non-injectable. In the second case, the cocktail penetrates the skin using a mesoscooter, mesoinjector or devices (special infrared laser, etc.). The injection version of the cocktail gives a more noticeable and prolonged effect, which is why cosmetologists prefer it. NCTF 135 HA+ infusion techniques – papular, superficial/median nappage or linear retrograde.

The drug is administered to the following areas:

• Face;
• Neck and décolleté area.

For mesotherapy of the scalp, NCTF 135 and NCTF 135 HA are most often used. Purposes of drug administration:

• Awakening the internal potentials of the skin;
• Enriching the skin with vitamins, minerals and other valuable nutrients;
• Deep hydration and nutrition of the skin;
• Optimization of cellular respiration, lymphatic drainage, local blood circulation;
• Acceleration of regenerative and proliferative processes in cells and tissues (especially important during rehabilitation after aggressive procedures and operations);
• Increased skin tone and turgor;
• Relief of pathological activity of the sebaceous and sweat glands;
• Cleansing and detoxification.

Indications for injections NCTF 135 HA+

Procedures using NCTF 135 HA+ are indicated for the following defects:

• Thinning, weakening, dehydration of the skin;
• Looseness, sagging, pasty skin;
• Gravitational ptosis of soft tissues of the face I-II degree;
• Sharp and obvious wrinkles, grooves, folds;
• “Stressed” skin (dullness and laxity of the skin in people living in metropolitan areas, working in air-conditioned rooms, experiencing chronic stress, and having a nicotine addiction);
• Degenerative skin changes in the pre- and postmenopausal period;
• Excessive oily skin;
• Open and closed comedones;
• Acne;
• Atrophic scars.

Like its predecessors, the mesotherapy cocktail NCTF 135 HA+ is available in sterile 3 ml bottles. One procedure requires from ½ to 1 bottle of the drug. The intensive course consists of 4-6 sessions with an interval of 2-3 weeks.

Main indications for use

The high therapeutic effect of Filorga nctf 135 products allows it to be used to solve a number of aesthetic problems starting from the age of 27-30. Indications for their use in mesotherapy procedures are:

1. Prevention of age-related changes, as well as light aging of the skin in people participating in extreme sports - alpine skiing, windsurfing, mountaineering.
2. Correction of skin relief, rosacea, correction of uneven coloring and reduction of the severity of fine wrinkles, thinning of the skin and its sagging due to low tone and dehydration (dryness).
3. Skin changes that occur as a result of frequent stressful situations, neuropsychic stress and overwork (chronic fatigue syndrome).
4. Preparation for irradiation with ultraviolet rays and complex treatment of solar (actinic) excess pigmentation.
5. Degenerative skin changes in women occurring in connection with the pre- and menopausal period.
6. Scalp and hair care (dandruff, seborrhea, focal and diffuse hair loss, androgenic alopecia).
7. Normalization of the secretion of sebaceous and sweat glands, acne,

As a preparation and rehabilitation, filorga mesotherapy is recommended and is actively used in combination with such cosmetic procedures as:

• contour plastic surgery (injection);
• chemical peels;
• plastic surgery;
• mechanical and laser grinding.

Very good results were obtained when used together (as tissue preparation and restoration), for example, with solutions of different concentrations for chemical peels “Glykopeel” from the same company. This can significantly improve the tolerability and results of procedures.

Effect of NCTF 135 HA+

A full course of mesotherapy with NCTF 135 HA+ gives the following results:

• Smoothing out small creases and wrinkles;
• Reduction of structural grooves and folds;
• Renewal and refreshment of the skin;
• Healthy complexion and light blush;
• Internal “highlighting” of the skin;
• Evens out skin tone and texture;
• Lightening of hyperpigmentation;
• Elimination of dark circles and puffiness under the eyes;
• Cleansing pores and removing comedones;
• Elimination of acne;
• Camouflage spots and acne scars.

Contraindications and side effects

NCTF series drugs cannot be used for:

• acute inflammatory diseases, as well as exacerbation of chronic pathologies;
• individual intolerance to the components present in the composition;
• oncological diseases;
• any pathologies accompanied by blood clotting disorders;
• undergoing anticoagulant therapy;
• pregnancy and breastfeeding.

When used correctly and contraindications are observed, NCTF 135 does not cause side effects. Possible side effects typical for injection effects:

• swelling;
• small hematomas at the injection sites;
• skin redness;
• unpleasant sensations.

In rare cases, an exacerbation of psoriasis and other chronic skin diseases is observed. If the sterility of the procedure is not observed, an infectious skin lesion may occur.

Typically, post-procedure symptoms disappear on their own after a couple of days. If this does not happen, then you should immediately contact a dermatologist.